Laryngeal Cancer And Papillomatosis

Laryngeal Cancer And Papillomatosis

Summarize

Pediatric laryngeal papillomatosis

 summary

        Recurrent laryngeal papillomatosis, the most common benign laryngeal tumor in children, is associated with human papillomavirus (HPV) infections, primarily HPV-6 and HPV-11. Compared to HPV-6, HPV-11 is linked to more aggressive clinical outcomes. These tumors are associated with wart-like nodules on the vocal cords, which can cause hoarseness. In rare cases, the tumors may extend into the lungs, leading to serious conditions. If left untreated, these tumors can progress to laryngeal cancer or squamous cell lung cancer.

Epidemiological

 histology

        Laryngeal tumors are rare, with the most common benign tumor being subglottic hemangioma. Malignant tumors are extremely rare and may be associated with benign tumors such as polyps and papillomas.

Etiology & Risk Factors

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Classification & Staging

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Clinical Manifestations

 clinical manifestation

        These tumors can cause hoarseness, difficulty swallowing and enlarged lymph nodes in the neck.

Clinical Department

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Examination & Diagnosis

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Clinical Management

Treatment of pediatric papillomatosis of larynx

         Papillomatosis is not a cancer. The primary treatments are surgical excision and laser vaporization. This type of tumor often recurs. While lung involvement is rare, it can occur. If a patient requires more than four surgeries per year, other interventions may be necessary, including the following:

Interferon therapy ​

Immunotherapy with hspE7. HspE7 is a recombinant fusion protein that has shown activity in other HPV-related diseases. An experimental study showed that this treatment can significantly increase the interval between surgical interventions.

Laser therapy combined with bevacizumab injection in the lesion

        The efficacy of idoxuridine injection in the lesion has not been definitively demonstrated. The role of immune checkpoint inhibitors, such as PD-1 inhibitors, is currently being studied. In some patients, the use of a quadrivalent HPV vaccine has been associated with complete or partial remission after initial surgery and increased the interval between surgeries

Prognosis

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Follow-up & Review

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Daily Care

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Cutting-edge therapeutic and clinical Trials

 clinical manifestation

        These tumors can cause hoarseness, difficulty swallowing and enlarged lymph nodes in the neck.

References

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Audit specialists

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